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Volume versus pressure controlled ventilation in liver recipients

Comparison of Alveolar to Arterial Oxygen Pressure gradient in Volume versus Pressure Controlled Ventilation in Liver Recipients

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/12/022456
Enrollment
75
Registered
2019-12-20
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K720- Acute and subacute hepatic failure Health Condition 2: K721- Chronic hepatic failure

Interventions

Intervention1: Pressure controlled mode of ventilation(PCV): PCV set to deliver a tidal volume of 7 ml/kg predicted body weight and respiratory rate adjusted to an ETCO2 of 30-35 mm Hg Control Interve

Sponsors

Amrita Institute of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Elective adult patients for liver transplant surgery

Exclusion criteria

Exclusion criteria: Patients in ALF Patients in early pulmonary oedema Documented Hepato-Pulmonary Syndrome History of previous lung surgery Patients with obvious thoracic wall abnormalities and Refusal to participate

Design outcomes

Primary

MeasureTime frame
To compare Alveolar to Arterial oxygen pressure gradient (A-a) DO2 between two ventilator strategies (volume controlled versus pressure controlled ventilation) in patients undergoing elective adult liver transplantTimepoint: 1. T0 Pre-induction 2. T1 10 m postintubation 3. T2 application of retractors 4. T3 start of anhepatic phase 5. T4 10m after reperfusion 6. T5 End of surgery 7. T6 Post extubation—

Secondary

MeasureTime frame
To asess 1. Arterial to End Tidal Carbon Dioxide pressure gradient 2. Peak airway pressure (Paw) 3. Dynamic compliance (Cdyn) 4. P/F ratio. Timepoint: T0 Pre-induction 2. T1 10 m postintubation 3. T2 application of retractors 4. T3 start of anhepatic phase 5. T4 10m after reperfusion 6. T5 End of surgery 7. T6 Post extubation—

Countries

India

Contacts

Public ContactLakshmi Kumar

Amrita Institute of Medical Sciences ad Research Centre

lakshmi.k.238@gmail.com04842856162

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026