Health Condition 1: A370- Whooping cough due to Bordetella pertussis
Conditions
Interventions
None listed
Sponsors
Dr Monjori Mitra
Eligibility
Inclusion criteria
Inclusion criteria: 1. All hospitalized infants in the age group of 0-6 months with or without fever presenting with either cough/cold or respiratory distress will be identified as potential subjects. 2. All potential subjects as per the above criteria will be screened and enrolled as per the CDC case classification below. Case Classification as per CDC, US. Probable In the absence of a more likely diagnosis, a cough illness lasting >=2 weeks, with o At least one of the following signs or symptoms: o Paroxysms of coughing; or inspiratory "whoopâ??; or o Post-tussive vomiting; or o Apnea (with or without cyanosis) (FOR INFANTS AGED And o Absence of laboratory confirmation; And o No epidemiologic linkage to a laboratory-confirmed case of pertussis. OR, FOR INFANTS AGED ï?· Acute cough illness of any duration, with o At least one of the following signs or symptoms: o Paroxysms of coughing; or o Inspiratory "whoop"; or o Post-tussive vomiting; or o Apnea (with or without cyanosis) And o Polymerase chain reaction (PCR) positive for pertussis. OR, FOR INFANTS AGED ï?· Acute cough illness of any duration, with o At least one of the following signs or symptoms: o Paroxysms of coughing; or o Inspiratory "whoop"; or o Post-tussive vomiting; or o Apnea (with or without cyanosis) And o Contact with a laboratory-confirmed case of pertussis. Confirmed ï?· Acute cough illness of any duration, with isolation of B. pertussis from a clinical specimen. OR ï?· Cough illness lasting >= 2 weeks, with o At least one of the following signs or symptoms: o Paroxysms of coughing; or o inspiratory "whoopâ??; or o Post-tussive vomiting; or o Apnea (with or without cyanosis) (FOR INFANTS AGED And o Polymerase chain reaction (PCR) positive for pertussis. OR ï?· Cough illness lasting >= 2 weeks, with o At least one of the following signs or symptoms: o Paroxysms of coughing; or o inspiratory "whoopâ??; or o Post-tussive vomiting; or o Apnea (with or without cyanosis) (FOR INFANTS AGED And o Contact with a laboratory-confirmed case of pertussis. Case Classification Comments Note: An illness meeting the clinical case definition should be classified as Probable rather than Confirmed if it occurs in a patient who has contact with an infant aged less than 1 year who is Polymerase Chain Reaction (PCR) positive for pertussis and has more than or equal to 1 sign or symptom and cough duration less than 14 days (classified as Probable case).
Exclusion criteria
Exclusion criteria: 1. Parents or guardians who are unwilling to give written informed consent for inclusion in the study. 2. Children in care-institutions and orphanages
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number and proportion of laboratory confirmed pertussis (i.e. RT-PCR) among hospitalized infants those who met the clinical case definition as per CDC .Timepoint: Duration of Hospitalization | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Number of probable cases of pertussis as per CDC case classification in the total number of hospitalized ARI cases during the study period 2. Socio economic status classification amongst both laboratory confirmed or clinically suspected cases of pertussis.. 3. Clinical profile and complications in lab confirmed and clinically suspected cases of pertussis in two different age strata (0-3 and 4-6 months)Timepoint: Duration of Hospitalization;Exploratory: Number and proportion of cases of RSV/ Influenza or other viruses identified as cases that fit the case definition of pertussisTimepoint: Duration of Hospitalization | — |
Countries
India
Contacts
Public ContactDr Monjori Mitra
Medclin Research Pvt. Ltd.
Outcome results
None listed