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Comparison of the effects of fractionated dose injection versus conventional single dose injection of bupivacaine for sub-arachnoid block in patients undergoing caesarean section

Comparison of haemodynamic parameters following fractionated versus single dose injection of bupivacaine for sub-arachnoid block in patients undergoing caesarean section

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/12/022406
Enrollment
80
Registered
2019-12-18
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O00-O9A- Pregnancy, childbirth and the puerperium

Interventions

Intervention1: FRACTIONATED DOSE INJECTION OF BUPIVACAINE FOR SUB-ARACHNOID BLOCK IN PATIENTS UNDERGOING CAESAREAN SECTION: Spinal anaesthesia will be administered with a standard technique in sitting

Sponsors

UCMS and GTB Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Full term pregnant patients (singleton) of the age group 18-35 years scheduled for lower segment caesarean section under spinal anaesthesia 2.Height in the range of 140cms- 170cms 3.ASA physical status grade I and II 4.Baseline systolic BP in the range of 110mmHg-130 mmHg

Exclusion criteria

Exclusion criteria: 1.BMI of >= 30 kg/m² 2.Pre-existing hypertension 3.Complicated pregnancy such as foetal distress, pregnancy induced hypertension, pre-eclampsia, eclampsia, cardiovascular, cerebrovascular disease, antepartum haemorrhage, hypovolemic shock, diabetes mellitus, etc. 4.Existing contraindication for spinal anaesthesia e.g. local infection, vertebral column deformity, etc.

Design outcomes

Primary

MeasureTime frame
Total dose of mephentermine required to maintain the systolic blood pressure more than 100mmHg in the two groupsTimepoint: every 2 minutes initially for 30 minutes and every 5 minutes thereafter throughout the procedure.—

Secondary

MeasureTime frame
Neonatal APGAR score in the two groupsTimepoint: at 1 minute and 5 minute of birth of the neonate;Number of episodes of bradycardia and the total dose of atropine required in the two groupsTimepoint: every 2 minutes initially for 30 minutes and every 5 minutes thereafter throughout the procedure.;Number of episodes of hypotension in the two groupsTimepoint: every 2 minutes initially for 30 minutes and every 5 minutes thereafter throughout the procedure.;Time required for complete onset of sensory and motor blockade in the two groupsTimepoint: every 2 minutes initially for 30 minutes and every 5 minutes thereafter throughout the procedure;Time taken for recovery of sensory and motor blockade in the two groupsTimepoint: every 15 minutes perioperatively till two segment regression from the highest blocked level—

Countries

India

Contacts

Public ContactDr GANGA DUTT D

University College Of Medical Sciences and Guru Teg Bahadur Hospital Delhi 95

mahendramohit@yahoo.com9868399709

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026