TO EVALUATE WHETHER ANALGESIC ACTION OF ONDANSETRON FOR PROPOFOL IS LOCAL OR CENTRAL.

EVALUATION OF PERIPHERAL OR CENTRAL ACTION OF ONDANSETRON AS PRETREATMENT TO PREVENT PAIN ON INJECTION OF PROPOFOL:A RANDOMIZED CONTROLLED STUDY

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/12/022386

Enrollment

Registered

2019-12-16

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Z76- Persons encountering health services in other circumstances

Interventions

Intervention1: SYSTEMIC ONDANSETRON PREATREATMENT: SYSTEMIC IV ONDANSETRON FOLLOWED 30 MINUTES LATER BY INTRAVENOUS SALINE AND VENOUS OCCLUSION. Control Intervention1: INTRAVENOUS ONDANSETRON PRETREAT

Eligibility

Inclusion criteria

Inclusion criteria: 1 Patients of ASA physical status I and II 2.Patients between 18 â?? 60 years of age of either sex 3.Patients willing to participate. 4.Patients scheduled to undergo Elective surgery/Day care surgery in whom Propofol is indicated.

Exclusion criteria

Exclusion criteria: 1.Patientâ??s refusal to participate 2.Patients with known sensitivity to ondansetron. 3.Patients on concomittent analgesics, sedative or antiepileptic medications. 4.Patients with ASA physical status III,IV

Design outcomes

Primary

Measure	Time frame
Incidence and severity of pain on injection of propofolTimepoint: 5 seconds	—

Secondary

Measure	Time frame
Heart rate,Mean arterial pressureTimepoint: Baseline, 5seconds	—

Countries

India

Contacts

Public ContactDR PRAKASH K DUBEY

drdeepak2006skmch@gmail.com8709468401

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026