A clinical trial to assess the benefits of a drug, intravenous lipid emulsion in patients presenting with pesticide (organophosphate) poisoning

EFFICACY OF INTRAVENOUS LIPID EMULSION ADMINISTRATION IN ORGANOPHOSPHATE POISONING â?? AN EXPLORATORY STUDY

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/12/022335

Enrollment

Registered

2019-12-12

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: T600- Toxic effect of organophosphate and carbamate insecticides

Interventions

Intervention1: intravenous lipid emulsion: 1.5 ml/kg of ILE within 2 minutes followed by 0.25 ml/kg/minute infusion till total dose of 10 ml/kg Control Intervention1: normal saline: normal saline bolu

Eligibility

Inclusion criteria

Inclusion criteria: 1. Adults patients (>= 18 years of age) presenting to the emergency department of AIIMS New Delhi 2. Moderate to severe symptoms of organophosphate poisoning (according to Peradeniya score) 3. Patients or legally authorized representative of patient willing to give consent.

Exclusion criteria

Exclusion criteria: 1. Patients presenting with cardiac arrest 2. Pregnant patients 3. Patients with chronic kidney disease and/or chronic liver disease 4. Patients with known allergy to soyabean oil

Design outcomes

Primary

Measure	Time frame
To assess the improvement in cardiorespiratory parameters after the administration of intravenous lipid emulsion in organophosphate poisoningTimepoint: 12 hours	—

Secondary

Measure	Time frame
To assess the change in level of serum amylase after giving intravenous lipid emulsionTimepoint: 12 hours;To assess the reduction in mortality after administration of intravenous lipid emulsionTimepoint: 7 days;To compare the dose of atropine required for atropinisation in patients receiving only atropine and atropine with intravenous lipid emulsionTimepoint: 7 days;To find the reduction in duration of requirement of ventilator supportTimepoint: 7 days	—

Measure

Time frame

To assess the change in level of serum amylase after giving intravenous lipid emulsionTimepoint: 12 hours;To assess the reduction in mortality after administration of intravenous lipid emulsionTimepoint: 7 days;To compare the dose of atropine required for atropinisation in patients receiving only atropine and atropine with intravenous lipid emulsionTimepoint: 7 days;To find the reduction in duration of requirement of ventilator supportTimepoint: 7 days

—

Countries

India

Contacts

Public ContactAkhil Neseem

All India Institute of Medical Sciences, New Delhi

peekay_124@hotmail.com9868397050

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026