Comparing the Magnesium Sulphate with Paracetamol and Fentanyl with Lignocaine in providing better outcome during endotracheal tube insertion in general anaesthesia

Comparison of Magnesium Sulphate with Paracetamol combination vs Fentanyl with Lignocaine combination in attenuating hemodynamic response during Laryngoscopy and Intubation - A prospective double blinded randomised controlled study

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/12/022315

Enrollment

Registered

2019-12-11

Start date

Unknown

Completion date

Unknown

Last updated

2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Magnesium Sulphate 25 mg/Kg IV Paracetamol 1Gm IV: Patients undergoing surgeries under general anaesthesia have been administered with Magnesium Sulphate 25mg/Kg intravenously and Parac

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age between 18 - 50 yrs of both sex 2. ASA I and II patients 3. Patients posted for elective surgeries under General Anaesthesia

Exclusion criteria

Exclusion criteria: 1. Heart rate less than 50/minute 2. Systolic blood pressure less than 100 mmHg 3. Presence of first, second and third degree heart block 4. History of obstructive lung disease 5. Patients on any cardiovascular medications 6. Any difficult airway

Design outcomes

Secondary

Measure	Time frame
To assess the effects of these drugs on any other complications (arrhythmias and delayed recovery) that may arise during laryngoscopy and intubation.Timepoint: 24 Hours	—

Primary

Measure	Time frame
To compare the effects of Magnesium sulphate with paracetamol and fentanyl with lignocaine on control of hemodynamic responses due to direct laryngoscopy and intubation.Timepoint: 15 minutes	—

Countries

India

Contacts

Public ContactRanjan R V

Pondicherry Institute Of Medical Sciences

ranjanrv2005@gmail.com9600823772

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026