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A clinical trial to study the effects of combination therapy with two drugs, oral prednisolone and fluticasone nasal spray in patients with chronic rhinosinusitis with polyposis

Effects of Oral Prednisolone and Fluticasone Nasal Spray in the Managanement of Chronic Rhinosinusitis with Polyposis.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2019/12/022305
Enrollment
50
Registered
2019-12-11
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R52- Pain, unspecified

Interventions

Intervention1: PREDNISOLONE TABLET, FLUTICASONE NASAL SPRAY: ORAL PREDNISOLONE 5MG TABLET IN TAPERING DOSES FOR 3 WEEKS AND FLUTICASONE NASAL SPRAY 200mcg TWO PUFFS FOR 3 WEEKS Control Intervention1:

Sponsors

JAWAHARLAL NEHRU HOSPITAL AND RESEARCH CENTRE
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients >18 years willing to take part and give written informed consent. 2. Patients with complains of nasal discharge, nasal obstruction, facial pain and decreased sense of smell for more than 12 weeks. 3. Patients with presence of bilateral moderate to large nasal polyps on Nasal Endoscopy.

Exclusion criteria

Exclusion criteria: 1. Patients not giving consent for our study. 2. Patients who have received medical treatment in last 4 months. 3. Patients who have undergone surgery in last 6 months. 4. Patients with contraindications and hypersensitivity to steroids. 5. Female patients who are pregnant, lactating or planning to become pregnant. 6. Patients with co-morbidities like Hypertension, Diabetes mellitus, Asthma, Tuberculosis, Epilepsy.

Design outcomes

Primary

MeasureTime frame
Reduction in nasal obstruction score after treatmentTimepoint: Reduction in Visual Analog Symptom score in follow up at 3 weeks and 2 months from baseline—

Secondary

MeasureTime frame
Reduction in Nasal Endoscopic and CT Scan Nose and Paranasal sinuses score after treatmentTimepoint: Reduction in Lund and Mackay scoring of Nasal Endoscopy and CT Scan of Nose and Paranasal Sinuses in follow up at 3 weeks and 2 months from baseline.—

Countries

India

Contacts

Public ContactDR ASHWIN ASHOK JAISWAL

JAWAHARLAL NEHRU HOSPITAL AND RESEARCH CENTRE

ash1978jaiswal@gmail.com9407983605

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026