Health Condition 1: G20- Parkinsons disease
Conditions
Interventions
None listed
Sponsors
Indian Council of Medical Research ICMR
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria for PD: (1) Diagnosis of PD (according to UKPDS Brain Bank Diagnostic criteria) (2) Early stages of the disease (Hoehn and Yahr stage 2.5 or lesser) (3) Age more than 60 years Inclusion-criteria for healthy volunteer controls : (1) Age and gender matched to PD patients (2) Normal neurological examination
Exclusion criteria
Exclusion criteria: Exclusion criteria for PD patients: (1) Any other significant neurologic disease, history of alcohol/substance dependence, major psychiatric disorders (including major depression), or any other significant medical illness. (2) Atypical or secondary Parkinsonism. (3) The use of systemic (oral or I/V) antibiotics in the previous 3 months (4) Corticosteroid use (oral, IV, nasal, or inhaled) or use of immune stimulating medications, immunosuppressive agents or large doses of commercial probiotics (5) Major dietary change during previous month (defined as eliminating or significantly increasing a major food group) (6) major GI tract surgery in past 5 years (with the exception of cholecystectomy and appendectomy) (7) Bowel resection at any time (7) active uncontrolled GI disorders or diseases including inflammatory bowel disease (IBD), indeterminate colitis, irritable bowel syndrome (IBS), persistent, infectious gastroenteritis, colitis or gastritis, persistent or chronic diarrhea of unknown etiology Exclusion-Criteria for Healthy volunteers: Same as for PD patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gut flora differences between Parkinsons disease patients and healthy volunteersTimepoint: At the time of recruitment | — |
Secondary
| Measure | Time frame |
|---|---|
| Metabolomic Profile of biological fluids (Serum, saliva, Urine)Timepoint: At the time of recruitment | — |
Countries
India
Contacts
Public ContactDr Syam Krishnan Nair
Sree Chitra Tirunal Institute for Medical Sciences and Technology
Outcome results
None listed