Health Condition 1: G890- Central pain syndrome
Conditions
Interventions
Intervention1: Low (20 mg) vs High (40mg) dose oral Prednisolone in CRPS: The patients fulfilling the inclusion criteria will be randomized to prednisolone 40mg (group I) or 20mg (group II) using rand
Sponsors
Prinicipal Investigator
Eligibility
Inclusion criteria
Inclusion criteria: The patients with CRPS I of shoulder joint attending neurology service will be included. A diagnosis of CRPS-I will be based on the following features 1. Pain and tenderness during humeral abduction, flexion, and external rotation. 2. Pain and dorsal swelling over the carpal bones. 3. Moderate fusiform edema of metacarpo-phalangeal and inter-phalangeal joints. 4. Change in temperature, color, and dryness of skin. 5. Loss of dorsal skin lines and change in nails
Exclusion criteria
Exclusion criteria: Patients with uncontrolled hypertension, diabetes, infection, organ failure, malignancy, shoulder joint dislocation or infection, children ( <18yrs), pregnancy and unwilling for consent will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| More than 50% improvements in VAS scoreTimepoint: 1 and 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement in CRPS score, disability score and sleep quality by Daily sleep Interference Scale (DSIS) Change in pro and anti-inflammatory cytokine levels Side effects Timepoint: 1 and 3 months | — |
Countries
India
Contacts
Public ContactJayantee Kalita
SGPGIMS Lucknow
Outcome results
None listed