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Comparison of neurological outcome with propofol and sevoflurane anesthesia techniques in patients undergoing decompressive craniectomy for acute stroke

Comparison of functional neurological outcome with propofol total intravenous anesthesia and sevoflurane based balanced anesthesia in adult patients undergoing decompressive craniectomy for supratentorial acute ischemic infarct: A randomized controlled pilot study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/12/022230
Enrollment
40
Registered
2019-12-03
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I633- Cerebral infarction due to thrombosis of cerebral arteries

Interventions

Intervention1: propofol total intravenous anesthesia arm: adult patients with acute supratentorial ischemic stroke undergoing decompressive craniectomy will receive 100-200mcg/kg/min propofol total in

Sponsors

Dept of Neuroaneshesiology and Critical Care AIIMS New Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: adult patients, 18-60 years of age with supratentorial acute ischemic infarct planned for decompressive craniectomy will be enrolled in the study

Exclusion criteria

Exclusion criteria: hemorrhagic infarct or infratentorial infarct or recurrent infarct will be excluded ASA physical status IV & V patients will be excluded

Design outcomes

Primary

MeasureTime frame
to compare functional neurological outcome using modified Rankin scale score of 0-3 as good neurological outcome in patients undergoing decompressive craniectomy for supratentorial acute ischemic infarct using propofol total intravenous anesthesia or sevoflurane based balanced anesthesiaTimepoint: at discharge from hospital and at three months from stroke onset—

Secondary

MeasureTime frame
to compare intraoperative brain relaxation in patients undergoing decompressive craniectomy for supratentorial acute ischemic infarct using propofol total intravenous anesthesia or sevoflurane based balanced anesthesiaTimepoint: will be compared intraoperatively;to compare systemic and intracranial pressure dynamics in patients undergoing decompressive craniectomy for supratentorial acute ischemic infarct using propofol total intravenous anesthesia or sevoflurane based balanced anesthesiaTimepoint: will be compared intraoperatively—

Countries

India

Contacts

Public ContactDr Sharma Pradeep Brijkishor

Dept of Neuroanesthesiology and Critical Care AIIMS New Delhi

drrajendrasinghchouhan@gmail.com9999069041

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026