To study the effectiveness of magnesium sulphate in the management of pain after a multilevel posterior spinal surgery , when the drug is injected into the veins by means of an electronic device which functions on patient demand.

Comparing the efficacy of magnesium sulphate as an adjuvant to fentanyl and ketamine in patient controlled analgesia for post operative pain management ,in patients undergoing multilevel posterior spinal fusion-A double blinded randomised controlled study.

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/11/022185

Enrollment

Registered

2019-11-27

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M818- Other osteoporosis without currentpathological fracture

Interventions

Intervention1: magnesium sulphate: PCA solution containing 20mcg/ml of fentanyl,0.01mg/kg/ml,20mg/ml of magnesium sulphate Control Intervention1: fentanyl and ketamine: PCA solution containing 20mcg/m

Eligibility

Inclusion criteria

Inclusion criteria: 1.patients undergoing multilevel posterior spinal fusion 2.ASA I and II 3.Age between 18-65 years 4.GFR (glomerular filtration rate ) >90ml/min/1.73m2

Exclusion criteria

Exclusion criteria: 1. ASA III and IV 2. GFR 3. Patients diagnosed with hypermagnesemia 4. Chronic opioid use 5. Allergy to study drugs 6. Inability to use PCA pumps.

Design outcomes

Primary

Measure	Time frame
post operative pain score at rest and on movement.Timepoint: post operative pain score at rest and on movement at 0,6,12,24,36 and 48 hours.	—

Secondary

Measure	Time frame
number of boluses administered at end of 24 hours,assessment of quality of sleep,post operative nausea and vomiting,sedation scores,chronic pain assessment.Timepoint: 0,6,12,24,36,48 hours and 3 months	—

Countries

India

Contacts

Public ContactShalaka Ashok Tembhurne

Christian Medical College ,Vellore

sajanpg@cmcvellore.ac.in04162282680

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026