Health Condition 1: L99- Other disorders of skin and subcutaneous tissue in diseases classified elsewhere
Conditions
Interventions
Intervention1: Nil: Nil
Sponsors
Jawaharlal Institute of Post graduate Medical Education and Research JIPMER Puducherry
Eligibility
Inclusion criteria
Inclusion criteria: Cases Subjects of more than 7 years of age, with a history of delayed cutaneous adverse drug reaction to antibiotics, classified as per as WHO-UMC drug causality assessment as certain/ probable, in clinical remission atleast 3 weeks after the acute event Controls Subjects more than 7 years of age, who had been exposed to and tolerated the corresponding antibiotics as the cases in the last twelve months without a history of drug hypersensitivity.
Exclusion criteria
Exclusion criteria: Patients on immunosuppressive treatment till 2 weeks before recruitment, known immunodeficiency states
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. To determine the diagnostic accuracy of Interferon gamma-Intracellular cytokine staining (IFN-γ-ICS) and cytokine bead array (CBA) in predicting the causal drug in drug hypersensitivity reactions. 2. To compare the utility of the IFN-γ ICS and CBA in terms of culprit drug confirmation in drug hypersensitivity reactions Timepoint: 3 years | — |
Secondary
| Measure | Time frame |
|---|---|
| NilTimepoint: Nil | — |
Countries
India
Contacts
Public ContactSivaranjini R
Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)
Outcome results
None listed