Levobupivacaine with nalbuphine and levobupivacaine with buprenorphine for spinal anaesthesia in abdominal surgeries

Comparison of analgesic efficacy of isobaric levobupivacaine with nalbuphine and isobaric levobupivacaine with buprenorphine in patients undergoing lower abdominal surgeries under subarachnoid block: A randomised controlled study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/11/022105

Enrollment

Registered

2019-11-21

Start date

Unknown

Completion date

Unknown

Last updated

2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K409- Unilateral inguinal hernia, without obstruction or gangrene

Interventions

Intervention1: Subarachnoid block will be given: Subarachnoid block will be given and intrathecal drug will be administered as per randomisation. One of the two group will receive isobaric levobupivac

Eligibility

Inclusion criteria

Inclusion criteria: Patients belonging to ASA grade I or II, between 18-65 years of age, and height 150-180 cm, about to undergo elective lower abdominal surgeries under subarachnoid block will be included in the study.

Exclusion criteria

Exclusion criteria: Patients who do not give consent for subarachnoid block. Patients with contraindications to subarachnoid block: infection at injection site, coagulopathy, space occupying lesion, increased intracranial tension, k/c/o seizure disorder, pre-existing neurological deficit, any spine deformity. Known case of hepatic and renal disease. On anti-arrhythmics. Drug addicts and chronic alcoholic. Hypersensitivity to any drugs used in the study.

Design outcomes

Primary

Measure	Time frame
Analgesic efficacy: Duration of effective analgesia (Time from the subarachnoid block to the time of patientÃ¢â?¬â?¢s first complaint of pain and VAS Ã¢â?°Â¥ 3).Timepoint: 0, 30, 60, 90 min postoperatively	—

Secondary

Measure	Time frame
Sensory block characteristics: Onset of sensory block, maximum height of sensory block, time to achieve maximum height of sensory block, time to two segment regression of sensory block. Motor block characteristics: Maximum motor block achieved, time to achieve maximum motor block, motor block at the time of rescue analgesia. Hemodynamic changes. Sedation score. Side effects like nausea, vomiting, pruritus, shivering, urinary retention and any other Timepoint: 0, 5, 10, 15, 20, 25, 30, 45, 60, 75, 90, 105, 120, 150, 180, 210, 240, 270 300 min	—

Measure

Time frame

Sensory block characteristics: Onset of sensory block, maximum height of sensory block, time to achieve maximum height of sensory block, time to two segment regression of sensory block. Motor block characteristics: Maximum motor block achieved, time to achieve maximum motor block, motor block at the time of rescue analgesia. Hemodynamic changes. Sedation score. Side effects like nausea, vomiting, pruritus, shivering, urinary retention and any other Timepoint: 0, 5, 10, 15, 20, 25, 30, 45, 60, 75, 90, 105, 120, 150, 180, 210, 240, 270 300 min

—

Countries

India

Contacts

Public ContactDr Neeraj Dahiya

University College of Medical Sciences

rsramb@gmail.com9625900699

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026