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Comparing two drug combinations for sedation and pain relief for bone biopsy under CT-scan.

Comparison of ketamine dexmedetomidine combination with fentanyl-dexmedetomidine combination for procedural sedation and analgesia during CT guided core biopsy: a randomized Control Trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/11/022038
Enrollment
60
Registered
2019-11-18
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C800- Disseminated malignant neoplasm, unspecified

Interventions

Intervention1: Ketamine: Intravenous bolus dose of ketamine (0.5mg/kg
analgesic dose) 1 min prior to LA infiltration by the interventionalist. A repeat dose of intravenous ketamine 0.25 mg/kg at 20 mins and 40 minutes post beginning of Bx, total duration of the proced

Sponsors

Dr Shagun Bhatia Shah
Lead Sponsor
Dr Rajiv Chawla
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: ASA I- II patients Weight 40-80 kg Either Sex Undergoing CT-guided core biopsy/RFA

Exclusion criteria

Exclusion criteria: Patients with raised intracranial tension Pre-existing psychiatric disorder Opioid dependence Geriatric age group(Age >60 yrs) Bradycardia (Heart Rate

Design outcomes

Primary

MeasureTime frame
Heart rate; Mean Arterial Pressure;Pain response;Respiratory rate;Arterial Oxygen SaturationTimepoint: 0 min(Baseline);10mins (After dexmedetomidine loading dose),14mins (1 minute post ketamine/ fentanyl boluses);15 mins (At Biopsy);25 mins (After 10 minutes of procedure);35 mins (After 20 minutes of procedure); 45 mins (After 30 minutes of procedure); 55 mins (After 40 minutes of procedure);65 mins (After 50 minutes of procedure);75 mins (At end of procedure)—

Secondary

MeasureTime frame
Visual Analog Score(VAS)at rest;Visual Analog Score(VAS)on coughing; Post-Operative nausea/Vomiting(PONV); Orientation; Aldrete ScoreTimepoint: After 75 mins(At The end of procedure)—

Countries

India

Contacts

Public ContactDr Shagun Bhatia Shah

Rajiv Gandhi Cancer Institute and Research Centre

shah.shagun@rgcirc.org9891769779

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026