Health Condition 1: C220- Liver cell carcinoma
Conditions
Interventions
None listed
Sponsors
Tata Memorial Hospital
Eligibility
Inclusion criteria
Inclusion criteria: CT/MRI scan TNM stage & Grade, Vascular invasion present/absent Liver Function Test (LFT): Total bilirubin, AST(SGOT)/ALT(SGPT), Alkaline phosphatase and gamma-GGT tests as per the institutional limit. At least one measurable lesion as defined by RECIST criteria Tumour size and tumour number.
Exclusion criteria
Exclusion criteria: Hepatitis, fibrosis, cirrhotic, fatty liver patients, other chronic liver diseases and alcoholic patients should be excluded for normal liver. No PET-CT scan 15 days prior to sample collection. No blood transfusion 30 days prior to sample collection. No concomitant radiation therapy or other systemic cancer therapies. Previous history of any malignancy none.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Establishment, characterization and validation of human hepatocellular carcinoma induced pluripotent stem cells and normal liver induced pluripotent stem cells.Timepoint: 2 Years | — |
Secondary
| Measure | Time frame |
|---|---|
| -To monitor the realâ??time effects of an imaging probe Quantum dot NP, and tracking the microtubules and microtubules motor proteins in the above mentioned stem cells. -Assessment of the efficacy of nanoformulations in HCC iPSCs using therapeutic drugs and its potential molecular targets. Timepoint: 2 Years | — |
Countries
India
Contacts
Public ContactMahesh Goel
Tata Memorial Hospital
Outcome results
None listed