To see if zinc supplementation has any role in reducing the number of wheezing(noisy breathing) episodes in children aged less than 5 years.

Zinc supplementation in under five recurrent wheezers: A randomized double blind placebo controlled trial.

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/11/021965

Enrollment

200

Registered

2019-11-11

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R098- Other specified symptoms and signsinvolving the circulatory and respiratory systems

Interventions

Intervention1: Supplementation of zinc in recurrent wheezing children 6-24 months: zinc 20mg/5ml(intervention drug) and placebo (comparator group) for 14 days then subsequent visit on 7th and 14th day

Eligibility

Inclusion criteria

Inclusion criteria: Children from 6 months to 5 years of age with history of recurrent wheezing.

Exclusion criteria

Exclusion criteria: 1. Children receiving zinc supplementation in past 3 months. 2.Children who are a.- severely malnourished. b.- On steroid therapy (last 7 days). c.- known immunodeficient. d- severely-ill children requiring hospitalization. 3.Clinical Suspicion of a.-congenital anomalies (vascular airway compression, primary ciliary dyskinesia) b.-Foreign body aspiration c. -Gastro esophageal reflux disease(h/o heart burn) d.-Tracheobronchomalacia.

Design outcomes

Primary

Measure	Time frame
To study effect of Zinc Supplementation in reducing the frequency of wheezing episodes in children.Timepoint: 14 days supplementation (drug/placebo) followed by 5 months follow up	—

Secondary

Measure	Time frame
To study in both groups: a) Duration of respiratory symptoms. b) Severity of wheezing episodes. - requirement for hospitalization - O2 requirement.Timepoint: 14 days supplementation (drug/placebo) followed by 5 months follow up	—

Countries

India

Contacts

Public ContactSomya Pandey

Era Lucknow Medical College and Hospital

garimapathak82@gmail.com08756867208

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026