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Magnesium Sulphate reduces the requirement of anaesthetic agents assessed using BIS analysis.

Effect of Magnesium Sulphate on consumption of anaesthetic agents under BIS targeted anaesthesia and post operative analgesia- a prospective randomized controlled study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/11/021951
Enrollment
100
Registered
2019-11-11
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H65-H75- Diseases of middle ear and mastoid

Interventions

Intervention1: Intravenous Magnesium Sulphate 40 mg/kg in 100 ml normal saline: Route ofadministration: Intravenous Magnesium Sulphate 40 mg/kg as infusion in 100 ml Normal saline over 15 minutes bef

Sponsors

Medical College and SSGHospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients posted for elective tympanomastoidectomy under general anaesthesia requiring endotracheal intubation (surgery duration of 2-3 hours) Weight : 50 to 70 kg ASA I & II Patient willing to participate in the study

Exclusion criteria

Exclusion criteria: Patients with systemic diseases like respiratory, cardiovascular, hepatic, renal dysfunction, epilepsy, neurological and neuromuscular disorders, Anticipated difficult airway, Postural hypotension, patients on sedatives, psychiatric medications patients with altered mental status H/o allergy to egg protein and drugs Pregnancy and lactating mother Patient’s unwillingness for participation

Design outcomes

Primary

MeasureTime frame
To see the requirement of anaesthetic agents intraoperatively– -Propofol -Vecuronium -Sevoflurane. Timepoint: For Propofol - following induction of anaesthesia. For Vecuronium - following induction and during maintenance of anaesthesia. For Sevoflurane - During maintenance of anaesthesia.—

Secondary

MeasureTime frame
Complications, if any.Timepoint: Intraoperatively Postoperatively upto 24 hours;Hemodynamic parameters like HR, BP, SpO2, RR and ECGTimepoint: Baseline After adjuvant infusion After induction Following intubation 3 min 5 min 7 min Every 10 min Before reversal Before extubation 10 min after extubation postoperatively every hourly upto 8 hours. ;Post operative analgesiaTimepoint: To Note Visual Analogue Scale score at postoperatively 0,2,4,6,8,12,18,24 hour.;Sedation score using Ramsay Sedation ScaleTimepoint: -Before adjuvant infusion -5 min after infusion -30 min post op—

Countries

India

Contacts

Public ContactAditi A Dhimar

Medical college and S.S.G.Hospital, Vadodara

dhimaraditi@yahoo.in9825334605

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026