Butorphanol and nalbuphine for tracheal intubation

Comparison of Butorphanol and nalbuphine for attenuation of haemodynamic response to laryngoscopy and tracheal intubation: A randomized controlled study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/11/021949

Enrollment

Registered

2019-11-11

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K353- Acute appendicitis with localizedperitonitis Health Condition 2: H721- Attic perforation of tympanic membrane Health Condition 3: K800- Calculus of gallbladder with acutecholecystitis Health Condition 4: H662- Chronic atticoantral suppurative otitis media

Interventions

Intervention1: Study drug will be administered before induction of anaesthesia : Drug will be diluted to 10 ml with 0.9% saline solution Control Intervention1: Butorphanol : 20 mcg/kg of butorphano

Eligibility

Inclusion criteria

Inclusion criteria: Sixty patients ASA I or II Modified Mallampati class I and II airway scheduled for elective surgery under general anaesthesia requiring tracheal intubation will be included.

Exclusion criteria

Exclusion criteria: Non-consenting patients History of allergy to opioids or sleep apnea History of cardiovascular, cerebral, renal, hepatic, bronchospastic or endocrine disease or psychiatric disorder. On anti-hypertensives, hypnotic or narcotic analgesics Full stomach patients, pregnant and lactating females.

Design outcomes

Primary

Measure	Time frame
Effect on heart rate (HR) and systolic blood pressure (SBP)Timepoint: T0 (baseline) T1 (After test drug administration) T2(before induction) T3(immediately before laryngoscopy) T4(after tracheal intubation) T5 (1 min) T6(3min) T7(5min) T8(10 min) T9(15min)	—

Secondary

Measure	Time frame
Effect on diastolic blood pressure (DBP) and mean arterial pressure (MAP) Effect on rate pressure product (RPP) Effect on post-operative sedation The side effects Timepoint: T0 (baseline) T1 (After test drug administration) T2(before induction) T3(immediately before laryngoscopy) T4(after tracheal intubation) T5 (1 min) T6(3min) T7(5min) T8(10 min) T9(15min)	—

Countries

India

Contacts

Public ContactDr Naveen Mathew A

UCMS and GTB Hospital

rsramb@gmail.com9625900699

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026