Health Condition 1: G20- Parkinsons disease
Conditions
Interventions
Intervention1: Real TMS: 10 Hz for 6 days
Control Intervention1: Sham TMS: The settings being used during real stimulation will be mimicked minus the actual stimulation. Thus sham stimulation will be
Sponsors
ICMR
Eligibility
Inclusion criteria
Inclusion criteria: 1. Diagnosis of clinically definite PD, defined by UKPD brain bank clinical and diagnostic criteria. With presence of at least 1 out of 3 cardinal motor features of PD (resting tremor, rigidity, and postural impairment like bradykinesia); 2. PD patients of both gender with H&Y stage above 1 to 2. 3. PD patients between age 45 to 75 on stable medication for at least 30 days.
Exclusion criteria
Exclusion criteria: 1. Features suggestive of other causes of Parkinsonism/ Parkinson-plus syndromes; 2. History of ICSOL (intracranial space occupying lesion) or brain surgeries, significant headaches, epilepsy or seizure disorder, mass lesions, or major head trauma leading to loss of consciousness of any length; 3. Family (1st degree relatives) history of epilepsy; 4. Presence of contraindications for functional magnetic resonance imaging (fMRI) like metal implants, and claustrophobia; 5. History of schizophrenia, schizoaffective disorder, other psychosis, rapid-cycling bipolar illness, alcohol/drug abuse within the past year; 6. Need for rapid clinical response due to conditions such as psychosis, or suicide tendency; 7. Patients with uncontrolled hypertension and diabetes and other uncontrolled medical illness. Patients with hypertension or diabetes would be included only if they are stable on medication for last six months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| UPDRS, PDQ 39, LED,Timepoint: Day 1 and Day 6 | — |
Secondary
| Measure | Time frame |
|---|---|
| MERTimepoint: During Scheduled DBS surgery;resting fMRITimepoint: Day 1 and Day 6 | — |
Countries
India
Contacts
Public ContactDr Vinay Goyal
AIIMS
Outcome results
None listed