Health Condition 1: H251- Age-related nuclear cataract
Conditions
Interventions
Intervention1: Bromfenac 0/09%: topical bromfenac 0.09% ophthalmic solution given as once daily and twice daily for 3 months
Control Intervention1: not applicable: not applicable
Sponsors
Dr Rajendra Prasad Centre for Ophthalmic Sciences
Eligibility
Inclusion criteria
Inclusion criteria: Senile Cataract
Exclusion criteria
Exclusion criteria: Ocular co-morbidity- active inflammation, glaucoma, corneal disorders or retinal pathology. History of any previous ocular surgery On any other topical ocular medication Systemic co-morbidity-Diabetes mellitus, collagen vascular diseases, heart disease, stroke etc Pregnancy and lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ocular pharmacokinetics of topical bromfenac 0.09% (once daily and twice daily dosing) Timepoint: stage 1- Samples will be taken during cataract surgery after 15 min, 30min, 1hr, 2hrs, 4hrs and 12 hrs after single drop of bromfenac 0.09% instillation stage 2 - samples will be collected after giving bromfenac 0.09% pre operatively for 5 days as once daily and twice daily | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain score, intra-operative miosis, post-operative anterior chamber flare and central macular thickness Timepoint: day 1, day 7, 1 month, 3month | — |
Countries
India
Contacts
Public ContactRajeswari Thangavel
All India Insitute of Ophthalmic Sciences
Outcome results
None listed