Health Condition 1: J329- Chronic sinusitis, unspecified
Conditions
Interventions
Intervention1: SINUSITIS ETIOLOGY: There is enough evidence in favor of the relationship between asthma and HLA but such association has not been clearly established in fungal sinusitis. Role of trace
Sponsors
AIIMS New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: This project will be conducted at AIIMS, New Delhi after approval from ethical committee. Total 200 patients will be recruited in study, out of 200, 50 patients will be included with diagnosis of sinusitis, 50 patients will be included with diagnosis of non-invasive fungal sinusitis and 50 patients will be included with diagnosis of invasive fungal sinusitis. For control, 50 blood samples will be collected from healthy individuals. All patients will be diagnosing by existing protocol in the department of Otolaryngology Head and Neck Surgery for sinonasal fungal disease. The current departmental practice for sinusitis is based on Rhinology society guidelines. Rhinology society proposed major and minor criteria to diagnose sinusitis. Fungal sinusitis is present with history of symptoms similar to sinusitis along with features of surrounding tissue invasion like orbit and brain. Invasive and non invasive fungal sinusitis is diagnosed on the basis of clinic radiological presentation and final conformation is based on histopathology. In non invasive fungal sinusitis radiology shows presence of heterogeneous characteristic mass in nose and paranasal sinuses with or without surrounding bone erosion. In comparison to invasive fungal sinusitis surrounding plane are maintained in non invasive fungal sinusitis.
Exclusion criteria
Exclusion criteria: 1- AGE BELOW 18 AND ABOVE 60 2-NOT WILLING FOR PARTICIPATION
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This study aims to identify the relationship between genetic factors, phagocytic function and trace elements and their role in the formation of sinusitis which will help us understand the disease process better and identify factors that affect aggressiveness of the disease. This study may direct us to establish treatment protocol for fungal sinusitis. Timepoint: 1-Sample collection- 20 months 2-Data evaluation- 4 months | — |
Secondary
| Measure | Time frame |
|---|---|
| nilTimepoint: nil | — |
Countries
India
Contacts
Public ContactHITESH VERMA
AIIMS, New Delhi
Outcome results
None listed