Health Condition 1: G700- Myasthenia gravis
Conditions
Interventions
Intervention1: Exercise: Exercise arm:
2-3 supervised walking sessions of 30 min., starting with 10 min. walking the
first week, 20 min. in second week and 30 min. in third week. After 4, 8 and 12 wee
Sponsors
Prinicipal Investigator
World Congress of Neurology
Eligibility
Inclusion criteria
Inclusion criteria: 1. MG patients attending the neurology Outdoor or indoor services of SGPGIMS. 2. MGFA score of stage II to III. 3. Able to undergo 6minute walk test
Exclusion criteria
Exclusion criteria: 1. Enrolled in another trial. 2. Contraindications to exercise like coronary artery disease and stroke and pulmonary disease, osteoarthritis, pregnancy or medical condition reducing survival to less than 2 years. 3. Hospitalization in past 8 weeks. 4. MGFA score of stage I, IV or V. 5. MGQOL score > 45.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MGQOL-15 scoreTimepoint: 1,2 and 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Increase in the dose of AchEIs drugs or additional immunosuppression or use of PE,IVIG. 2. Myasthenic muscle score: at 1,2 and 3 month. 3. Change in MGADL. 4. Grip strength. 5. Six min walk test. 6. RNS in Trapezius 7. Micro RNA: -150 -5P and micro RNA- 21- 5P. 8. Endorphin and its receptors.Timepoint: 1,2 and 3 months | — |
Countries
India
Contacts
Public ContactDr Usha Kant Misra
SGPGIMS Lucknow
Outcome results
None listed