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Effect of add on intravenous lignocaine on delirium and cognitive dysfunction after surgery in patients undergoing total hip replacement: a double blinded randomised controlled trial

Effect of add on intravenous lignocaine on post operative delirium and cognitive dysfunction in patients undergoing total hip replacement: a double blinded randomised controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/10/021816
Enrollment
80
Registered
2019-10-30
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M161- Unilateral primary osteoarthritisof hip

Interventions

Intervention1: IV lignocaine: Lignocaine IV bolus at 1.5 mg/kg for 10 minutes followed by an infusion of 1.5 mg /kg till the end of surgery Control Intervention1: normal saline: Bolus of normal saline

Sponsors

Eslavath Madhurima
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All patients above 18 years undergoing Total Hip Replacement.

Exclusion criteria

Exclusion criteria: Preexisting neurocognitive dysfunctions, Refusal for the consent , Auditory or visual disability, NuDESC score >2 pre-operatively, MMSE score Subjects with known sensitivity to lignocaine, On beta blocker therapy, Hemodynamically unstable, Subjects with deranged liver, renal functions THR done under general anaesthesia.

Design outcomes

Primary

MeasureTime frame
To evaluate the effect of intravenous lignocaine on the incidence of Post-operative Delirium(POD) and Post-Operative Cognitive Dysfunction(POCD) in patients undergoing Total Hip replacement(THR) Timepoint: 2 hours after the surgery—

Secondary

MeasureTime frame
1.Time to first analgesic demand (defined as time from spinal anaesthesia to first requirement of analgesia) 2.Side effects such as bradycardia, hypotension etc., Timepoint: time of requirement of analgesia,bradycardia, hypotension with in 24 hours after the surgery—

Countries

India

Contacts

Public ContactEslavath Madhurima

All India Institute of Medical Sciences, Bhubaneswar

masterbasu23@rediffmail.com7873285687

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026