Holistic Neuropsychological Rehabilitation for Patients with Epilepsy

Development and Efficacy of Holistic Neuropsychological Rehabilitation for Improving Cognition and Quality of Life in Patients of Drug Refractory Epilepsy (DRE): A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/10/021777

Enrollment

Registered

2019-10-23

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G408- Other epilepsy and recurrent seizures

Interventions

Intervention1: Experimental Group: 6-week structured neuropsychological rehabilitation intervention along with standard pharmacological treatment. Control Intervention1: Control Group: The control gro

Eligibility

Inclusion criteria

Inclusion criteria: a) Age: 18-45 years b) Education: Primary and above c) Language: Hindi or English d) Handedness: Both e) Definition of DRE from according to ILEA: a failure of adequate trials of two tolerated and appropriately chosen and used AED schedules (whether as monotherapies or in combination) to achieve sustained seizure freedomâ?? (Kwan et al., 2010) f) Age of onset: Diagnosis of epilepsy made at least in the last 1.5-2 years g) Surgical approach: Resection for temporal or extratemporal epilepsy h) Time since surgery: At least 3 months i) Primary caregiver with capacity and willingness to carry out home based activities j) Visual and auditory acuity for neuropsychological testing k) Capacity and willingness to consent l) Impairment in memory/attention m) Availability of smartphone/laptop (for patients recruited after onset of COVID-19 pandemic)

Exclusion criteria

Exclusion criteria: a) IQ b) Any significant progressive disorders or unstable medical conditions requiring acute intervention c) Hourly seizures

Design outcomes

Primary

Measure	Time frame
Auditory Verbal Learning Test (AVLT), Everyday Memory Questionnaire (EMQ), Quality of Life in Epilepsy (QOLIE-31), Hamilton Anxiety Inventory (HAM-A), Hamilton Depression Inventory (HAM-D)Timepoint: Pre intervention, 5 months post intervention (EMQ, QOLIE-31, HAM-D, HAM-A), 6-7 months post intervention (AVLT, EMQ, QOLIE-31, HAM-A, HAM-D)	—

Secondary

Measure	Time frame
Word Lists, Digit Span, Everyday Memory Questionnaire (EMQ), Quality of Life in Epilepsy-31 (QOLIE-31), Hamilton Anxiety Inventory (HAM-A), Hamilton Depression Inventory (HAM-D) - (For all patients recruited after onset of COVID-19 pandemic)Timepoint: Pre Intervention, 3 months post intervention	—

Countries

India

Contacts

Public ContactShivani Sharma

All India Institute of Medical Sciences

shivanisharma92@gmail.com9818830962

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026