Health Condition 1: - Health Condition 2: K74- Fibrosis and cirrhosis of liver
Conditions
Interventions
Intervention1: Terlipressin-3d arm: Patients will receive intravenous bolus terlipressin for 1 mg every 4 hours from the time of admission, and it will continue for 72 hours.
Control Intervention1: Te
Sponsors
Dr Shalimar
Eligibility
Inclusion criteria
Inclusion criteria: 1. (compensated or decompensated) with acute variceal bleeding 2. Willing to participate in the study
Exclusion criteria
Exclusion criteria: 1. Variceal bleeding secondary to causes other than cirrhosis. eg, extrahepatic venous obstruction, hepatic venous outflow tract obstruction 2. Patients with malignancy/disseminated intravascular coagulation (DIC)/known coagulopathic disorder (hemophilia) apart from cirrhosis. 3. History of intake of platelets inhibitors (e.g., aspirin, clopidogrel) and drugs affecting coagulation cascade (e.g., vitamin K antagonists) within the past 7 days 4. Pregnant women 5. Patients with chronic renal failure 6. Patients with shock or requiring mechanical ventilation 7. Sepsis 8. Acute on chronic liver failure 9. Hepatorenal syndrome 10. Hepatic encephalopathy 11. Contraindication to endoscopy 12. Not willing to provide consent 13. Active angina, Recent Myocardial infarction or dynamic EKG changes 14. Failure to control variceal bleed on initial endoscopy 15. Isolated gastric variceal bleeding 16. Spontaneous bacterial peritonitis at presentation 17. Hepatocellular carcinoma or other liver metastatic malignancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Control of variceal bleeding at 24 hours and 5-days.Timepoint: 1.Control of variceal bleeding at 24 hours and 5-days. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Rebleeding and mortality at 6 weeks. 2. Difference in hepatic venous pressure gradient between the 2-groups at 1, 2 and 3 days post endoscopic variceal band ligationTimepoint: 6 weeks | — |
Countries
India
Contacts
Public ContactDr Piyush Pathak
All India Institute of Medical Sciences
Outcome results
None listed