Health Condition 1: E210- Primary hyperparathyroidism
Conditions
Interventions
Intervention1: Injection Zoledronic acid (5mg/100 mL): Injection Zoledronic acid (5mg/100 ml) intravenous infusion over 30 minutes to be given once before surgery
Control Intervention1: 100 mL Normal
Sponsors
PGIMER Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: Patients with biochemically proven primary hyperparathyroidism fulfilling criteria to undergo surgery Hypercalcemia ( Calcium levels > 11 mg/dL)
Exclusion criteria
Exclusion criteria: Renal dysfunction (Creatinine clearance Pregnancy or lactation. Patients who have received any other bisphosphonates or antiresorptive therapy within a year before surgery. Patients developing permanent hypoparathyroidism after surgery Failed surgery Any chronic disease that may affect bone health significantly.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone mineral density at 1 year Incidence of hungry bone syndromeTimepoint: 1 year | — |
Secondary
| Measure | Time frame |
|---|---|
| Biochemical and bone turnover markers between the two groups Change in bone microarchitecture and remodelling rate between the two groups on bone biopsyTimepoint: 1 year | — |
Countries
India
Contacts
Public ContactDr Akanksha Gautam
PGIMER Chandigarh
Outcome results
None listed