Health Condition 1: M170- Bilateral primary osteoarthritis of knee
Conditions
Interventions
Intervention1: Group I (intra-osseous, intra-articular PRP Group): Under aseptic conditions, total 18 ml of PRP (8ml of intra-articular and 10 ml intra-osseous) will be infiltrated into the target kne
Sponsors
Indian Council Medical Research
Eligibility
Inclusion criteria
Inclusion criteria: The diagnosis of OA will be based on the American College of Rheumatology (ACR) criteria for OA Knee. Persons with OA Knee with the following features will be included in the study 1) OA Knee (Grade II/III, Radiological Kellgren and Lawrence (K/L) classification), age between 40-65 years and are able to walk with painful knee, 2)Having persisting knee pain >= 30mm on a 0-100mm VAS (when asked â??how painful is your knee during level walking?â??), 3)Willing to participate in all assessment If both knees involved, participants may choose one or both knees to be treated.
Exclusion criteria
Exclusion criteria: Persons with OA Knee with following features will be excluded from the study 1.Severe OA Knee (Grade IV, K/L classification) 2.Haemoglobin level 3.Inflammatory or post-infectious knee arthritis 4.History of prior knee replacement or repair 5.Prior fracture of the knee joint 6.Any Knee injection within 3 months 7.Daily use of opioid medication 8.Coexisting backache, other chronic pain disorder 9.Body mass index (BMI) >=40 kg/m2 10.Blood disorders, hematological, cardiac, hepatic or renal disorders. 11.Persons who receive oral, topical or intra-articular steroid last four weeks, pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale (VAS)Pain Score (0-100)Timepoint: Baseline visit (V0), 6 weeks(V1) and 12 weeks(V2)post intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| Knee injury and Osteoarthritis Outcome Score (KOOS) (0-100)Timepoint: Baseline visit (V0), 6 weeks(V1) and 12 weeks(V2)post intervention;Quantifications of Serum (s-) Biomarkers (s-hsCRP, s-PIIANP, s-COMP, s-HA)Timepoint: Baseline visit (V0), 6 weeks(V1) and 12 weeks(V2)post intervention;Quantifications of Urinary (u-)Biomarkers( u-CTX, u-NTX)Timepoint: Baseline visit (V0), 6 weeks(V1) and 12 weeks(V2)post intervention;USG findings of the target Knee jointTimepoint: Baseline visit (V0), 6 weeks(V1) and 12 weeks(V2)post intervention | — |
Countries
India
Contacts
Public ContactApurba Barman
AIIMS Bhubaneswar
Outcome results
None listed