Health Condition 1: F439- Reaction to severe stress, unspecified Health Condition 2: F439- Reaction to severe stress, unspecified
Conditions
Interventions
Intervention1: Dexmedetomidine nebulization: Group I Patient will be nebulized at night with dose of dexmedetomidine 1µg/kg diluted upto 4ml by normal saline
Route of administration-inhalational
Fr
Sponsors
AIIMS Patna
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age 18 to 60 2. Admitted to the ICU of more than 48 hours 3. Non-intubated patient
Exclusion criteria
Exclusion criteria: 1. Elderly patients age >60 2. Preexisting cognitive impairments 3. Allergic to dexmedetomidine 4. Inability to obtain informed consent 5. Hearing impaired, legally blind 6. admitted with alcohol intoxication, prisoners, Psychiatric disorder 7. Haemodynamic instability, bradyarrhythmias (Heart rate 8. Presence of delirium [Intensive Care Delirium Screening Checklist- (ICDSC >4)], RASS: Richmond Agitation Sedation Scale (RASS) 9. History of epilepsy, Acute alcohol withdrawal requiring benzodiazepine administration, history of hepatic encephalopathy, irreversible brain disease consistent with severe dementia, admitted with primary neurologic condition or injury (e.g., intracranial hemorrhage) 10. Current treatment with dexmedetomidine or clonidine 11. Unstable intubated patients, terminally ill, patients undergoing major surgery 12. Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients who remained free of delirium during their critical illness (i.e., ICU admission).Timepoint: Daily at 7am and 7pm for initial 5 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Sedation score (RASS) and midazolam consumptionTimepoint: Sedation score from 10pm to 7am for initial 5 days | — |
Countries
India
Contacts
Public ContactDr Neeraj Kumar
AIIMS Patna
Outcome results
None listed