Health Condition 1: L089- Local infection of the skin and subcutaneous tissue, unspecified
Conditions
Interventions
Intervention1: purified protein derivative(10 TU/0.1ml): Injection of 0.1 ml of purified protein derivative(10 TU/0.1ml) intradermally into the deltoid area of alternate arm,every 15 days for a total
Sponsors
GCS Medical college
Eligibility
Inclusion criteria
Inclusion criteria: Patients of either sex, aged more than 18 years ,suffering from chronic and relapsing dermatophytosis,confirmed by positive 10% potassium hydroxide mount for fungal hyphae
Exclusion criteria
Exclusion criteria: 1. Pregnant and lactating females 2. Patients with liver or renal failure or any malignancy 3. Patients with primary or acquired immunodeficiency 4. Patients with any major medical illness or surgical intervention within the preceding 4 weeks 5. Patients on concomitant medications which can interfere with immune response(eg steroids,immunosuppressants,chemotherapeutic agents) 6. Patients with a past history of tuberculosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All the patients in both the groups shall be assessed for 1 Complete Clearance of the dermatophytosis(assessed by Grade of improvement scoring,physicians and patientsglobal assessment score) at the end of 8 weeks 2) Reduction in the Itch score at the end of 8 weeks 3) Percentage of patients have having clinical relapse at 4,8,12 weeks after the last Intradermal PPD injection Timepoint: 1 Complete clearance of the infection at 8 weeks 2 Absence of relapse at 12 and 20 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Correlation of serum IgE levels and personal and family history of atopy with the primary outcome measures. 2) Correlation of preceding topical steroid use with the primary outcome parameters 3) Correlation of pre-study PPD positivity with the primary outcome measures. Timepoint: 8 and 20 weeks | — |
Countries
India
Contacts
Public ContactDr Kalgi Baxi
GCS Medical college and hospital
Outcome results
None listed