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Hypothyroidism and non-surgical periodontal theray

Effect of Non-surgical periodontal therapy on Serum level of IL-6 and TNF-α in chronic periodontitis patients with and without Hypothyroidism

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/10/021557
Enrollment
40
Registered
2019-10-07
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- 1.Chronic periodontitis group 2.Chronic periodontitis with hypothyroidism Health Condition 2: E039- Hypothyroidism, unspecified

Interventions

Intervention1: Non Surgical Periodontal Therapy (scaling and root planing): Scaling and root planing done on the first appointment in chronic periodontitis patients with and without Hypothyroidism Con

Sponsors

RS Indhuja
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with chronic periodontitis will be diagnosed according to the criteria of 1999 AAP 1.Attachment loss of >= 5 mm at more than 30% of the sites 2.Patients with bleeding on probing 3.Patients with >= 20 functional teeth Patients with Hypothyroidism: 1.Based on lab examination of TSH, fT3, fT4 in hypothyroidism patients 2.Thyroid function test Normal values: 1.TSH(serum) - 0.4 to 4.5 mU/L 2.fT4 - 9.0 to 25.0 Pmol/L 3.fT3 - 3.5 to 7.8 Pmol/L 4.TSH - elevated in hypothyroidism 5.fT4 and fT3 - reduced in hypothyroidism

Exclusion criteria

Exclusion criteria: • They suffer from any systemic condition except hypothyroidism that could affect the progress of periodontal diseases. • Smokers and former Smokers • Alcoholics and former alcoholics • Obese, pregnant and lactating woman • Subjects over 60 years of age • Patients presenting any kind of inflammatory disease within last 3 months • They had received professional periodontal treatment during the 6 month period prior to the study.

Design outcomes

Primary

MeasureTime frame
Non surgical periodontal therapy in chronic periodontitis patients with and without hypothyroidism showed decreased level of IL-6 and TNF-alphaTimepoint: within 30 days of time interval, Non surgical periodontal therapy in chronic periodontitis patients with and without hypothyroidism showed decreased level of IL-6 and TNF-alpha—

Secondary

MeasureTime frame
Enhance the thyroid status and Oral health of the patient.Timepoint: 3 months—

Countries

India

Contacts

Public ContactRS Indhuja

Sree Mookambika Institute of Dental Sciences

sadasivan_arun@hotmail.com9847246961

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026