A study to compare two drugs, Dexamethasone and Midazolam along with Bupicavaine in nerve block given to patients undergoing surgeries of upper limb.

A Comparative study of Dexamethasone versus Midazolam as adjuvant to 0.5% bupivacaine in Ultrasound guided Supraclavicular brachial plexus block for upper limb surgeries

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/10/021555

Enrollment

Registered

2019-10-07

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S529- Unspecified fracture of forearm

Interventions

Intervention1: 0.5% bupivacaine with Dexamethasone: Brachial plexus on the affected limb identified preoperatively using ultrasound guidance.Inj 0.5% bupivacaine 18ml along with 4 mg(1ml) of inj dexam

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients who are willing to give written informed consent 2) Patients of age 18 - 60 years of either sex 3) American society of anaesthesiologists(ASA) grade I and II 4) Patients with height 150-180cms and weight 50-80kg. 5) Patients undergoing elective upper limb surgeries.

Exclusion criteria

Exclusion criteria: 1) Patients not willing to give written informed consent 2) Patients with any contraindications for peripheral nerve block 3) Allergy to the study drug 4) Coagulation disorders 5) Cardiogenic or hypovolemic shock 6) Respiratory insufficiency

Design outcomes

Secondary

Measure	Time frame
Duration of motor blockTimepoint: Assessed every 15 minutes intraopetatively and every hour upto 24 hours postoperatively;Haemodynamic impact after drug administration Timepoint: Every 5 minutes till the end of surgery. Every hour upto 12 hours postoperatively;Onset of motor blockTimepoint: Assessed every minute till onset of motor block is seen;Onset of sensory blockTimepoint: Assessed every minute till onset of sensory block is seen;Side effects of drug if anyTimepoint: Every minute intraopetatively, every hour postoperatively upto 12 hours	—

Measure

Time frame

Duration of motor blockTimepoint: Assessed every 15 minutes intraopetatively and every hour upto 24 hours postoperatively;Haemodynamic impact after drug administration Timepoint: Every 5 minutes till the end of surgery. Every hour upto 12 hours postoperatively;Onset of motor blockTimepoint: Assessed every minute till onset of motor block is seen;Onset of sensory blockTimepoint: Assessed every minute till onset of sensory block is seen;Side effects of drug if anyTimepoint: Every minute intraopetatively, every hour postoperatively upto 12 hours

—

Primary

Measure	Time frame
1)Total duration of analgesia Timepoint: Every 10 minutes till the end of surgery. Every hour up to 24 hours postoperatively	—

Countries

India

Contacts

Public ContactDR THEJESH H J

Bangalore Medical College And Research Institute

kanthu.hirenallur@gmail.com9739006556

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026