Favorable / suitable amount of injection Ephedrine to be given as a precaution to avoid lowering of blood pressure soon after spinal anaesthesia during caesarean secton in pregnant patients

Optimal dose of prophylactic ephedrine to prevent spinal induced hypotension during caesarean section

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/10/021524

Enrollment

120

Registered

2019-10-03

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O82- Encounter for cesarean delivery without indication

Interventions

Intervention1: EPHEDRINE INTRAVENOUS INJECTION: intervention of comparison of the effects of the multiple doses of injection Ephedrine(5mg/7.5mg/10mg and equal volume of normal saline as control) by a

Eligibility

Inclusion criteria

Inclusion criteria: All patients 18-45 years, scheduled for LSCS procedures under spinal anaesthesia belonging to ASA Grade I and Grade II will be included in the study.

Exclusion criteria

Exclusion criteria: 1. Parturients with gestational age 2. High risk pregnancy 3. Known Hypertension 4. Preexisting cardiac or pulmonary disease 5. Any other contraindication of spinal anaesthesia 6. ASA physical status III and IV

Design outcomes

Primary

Measure	Time frame
7.5 mg of injection Ephedrine will be a more effective optimal intravenous prophylactic dose than other bolus doses and equal volume of normal saline that is to be administered to LSCS patients soon after spinal anaesthesia to avoid spinal induced hypotension.Timepoint: 1 Incidence of hypotension	—

Secondary

Measure	Time frame
1. 7.5mg of IV Ephedrine will bring a better haemodynamic stability. There will be no significant differences in baseline HR and systolic BP with 7.5mg iv bolus ephedrine in comparison to other study groups. 2. There will be no significant differences in sensory block height with 7.5mg iv bolus ephedrine 3. The incidence of nausea and vomiting and statistical differences of neonatal outcome at 1min and 5min Apgar scores will be lower with 7.5mg IV ephedrineTimepoint: 5 Heart rate and Blood pressure Sensory block height Apgar score Incidence of nausea Incidence of vomiting	—

Measure

Time frame

1. 7.5mg of IV Ephedrine will bring a better haemodynamic stability. There will be no significant differences in baseline HR and systolic BP with 7.5mg iv bolus ephedrine in comparison to other study groups. 2. There will be no significant differences in sensory block height with 7.5mg iv bolus ephedrine 3. The incidence of nausea and vomiting and statistical differences of neonatal outcome at 1min and 5min Apgar scores will be lower with 7.5mg IV ephedrineTimepoint: 5 Heart rate and Blood pressure Sensory block height Apgar score Incidence of nausea Incidence of vomiting

—

Countries

India

Contacts

Public ContactDr BIMAL KRUSHNA PANDA

VIMSAR,BURLA

drbimalpanda@gmail.com9437175425

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026