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The project intends to look for biological markers in the urine and blood that can detect kidney injury in the transplanted kidney in patients undergone kidney transplantation surgery

To study the pattern of FOXP3, OX40, PD1 and TIM-3 among renal allograft patients and its correlation with risk of kidney injury

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2019/10/021519
Enrollment
40
Registered
2019-10-03
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N185- Chronic kidney disease, stage 5

Interventions

Intervention1: NIL: NIL

Sponsors

Intra Mural Grant from All India Institute of Medical Sciences New Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients must be aged above 18 2. Patients willing to participate in the study 3. Immunologic higher risks (PRA > 20%, HLA mismatches >= 1). 4. Cross match negative

Exclusion criteria

Exclusion criteria: 1. Patients who do not provide consent for the study 2. Age group 3. Non-renal allograft patients 4. No Urine output

Design outcomes

Primary

MeasureTime frame
To assess the pattern of blood and urine biomarker (FOXP3, OX40, PD1 and TIM3) excretion among post renal allograft patients at different time pointTimepoint: 0 day 5th day 9th day 14th day—

Secondary

MeasureTime frame
To correlate the biomarker expression with biopsy proven acute kidney allograft injury (acute allograft rejection or acute tubular necrosis or calcineurin-inhibitor nephrotoxicity) during post transplantation surgeryTimepoint: 0 day 5th day 9th day 14th day—

Countries

India

Contacts

Public ContactMANJUNATH MARUTI POL

All India Institute of Medical Science New Delhi

manjunath.pol@gmail.com9990187137

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026