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To examine changes in neurocognitive functions after cranial radiation therapy.

A Prospective observational study of longitudinal assessment of neurocognitive function in patients with 1-4 brain metastases of NSCLC treated with cranial irradiation.

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2019/10/021511
Enrollment
200
Registered
2019-10-03
Start date
Unknown
Completion date
Unknown
Last updated
2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C349- Malignant neoplasm of unspecifiedpart of bronchus or lung

Interventions

None listed

Sponsors

Tata Memorial Center
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Pathologically proven diagnosis of NSCLC Age more than or equal to 18 years Karnofsky Performance status more than 70

Exclusion criteria

Exclusion criteria: Prior radiosurgery, whole brain radiotherapy, or cranial radiotherapy Previous surgical resection of brain metastasis (biopsy is allowed)

Design outcomes

Primary

MeasureTime frame
To compare neurocognitive function as measured by neurocognitive decline on a Hopkins Verbal Learning Test-Revised (HVLT-R) for Total Recall, delayed recall and delayed recognition from baseline to 3 monthsTimepoint: 3 months—

Secondary

MeasureTime frame
1. To compare neurocognitive function using different neurocognitive battery tests from baseline to 3,6, 9 and 12 monthsTimepoint: 3,6, 9 ad 12 months—

Countries

India

Contacts

Public ContactAnil Tibdewal

Tata Memorial Hospital

aniltibdewal@gmail.com022-24177000

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026