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Comparison of two doses of Dexmedetomidine to assess change in blood pressure as a response during vocal cord surgeries

Comparison of two dosages of Dexmedetomidine in attenuating haemodynamic response in patients undergoing microlaryngeal surgeries: A double blinded ; Randomized Controlled Clinical Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/10/021485
Enrollment
80
Registered
2019-10-01
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: D141- Benign neoplasm of larynx Health Condition 2: C320- Malignant neoplasm of glottis

Interventions

Intervention1: Two dose of Dexmedetomidine: All participants will receive a loading dose of 1mcg/kg of Dexmedetomidine intravenously over 10 mins and will be divided into 2 groups. Group A will be adm

Sponsors

Jawaharlal institute of postgraduate medical education and research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anaesthesiologists- Grade I and II

Exclusion criteria

Exclusion criteria: 1. Patients with baseline hemodynamic instabilities(Heart Rate 2. Tracheostomized patients 3. Allergy to Dexemedetomidine 4. Co-existing cardiac, hepatic and renal dysfunctions 5. History of cerebro-vascular accidents

Design outcomes

Primary

MeasureTime frame
To compare the effect of two dosages of Dexmedetomidine infusion (0.5mcg/kg/hr vs 0.7mcg/kg/hr) on mean arterial pressures in patients undergoing microlaryngeal surgeriesTimepoint: 1. At 0 min(loading dose) 2. At 5 mins after loading dose 3. At 10 mins after loading dose 4. At start of Dexmedetomidine infusion 5. At the time of induction with Propofol 6. Every 1min till 5 mins after intubation 7. At introduction of suspension laryngoscopy 8. 1 min after microlaryngoscopy 9. 5mins after microlaryngoscopy 10. Every 5 mins thereafter till the end of surgery 11. At extubation—

Secondary

MeasureTime frame
1. To compare the effect of two dosages of Dexmedetomidine (0.5mcg/kg/hr vs 0.7 mcg/kg/hr) on heart rate in patients undergoing microlaryngeal surgeries. 2. To compare the incidence of cough as a quality of extubation using a 5-point cough scale. 3. To compare the recovery times in both groupsTimepoint: 1. At 0 min(loading dose) 2. At 5 mins after loading dose 3. At 10 mins after loading dose 4. At start of Dexmedetomidine infusion 5. At the time of induction with Propofol 6. Every 1min till 5 mins after intubation 7. At introduction of suspension laryngoscopy 8. 1 min after microlaryngoscopy 9. 5mins after microlaryngoscopy 10. Every 5 mins thereafter till the end of surgery 11. At extubation—

Countries

India

Contacts

Public ContactDr D Sushmitha

Jawaharlal institute of postgraduate medical education and research

dr.chitrarajeswari@gmail.com9585887311

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026