Effect of oxygen in pulmonary hypertension due to heart disease.

Effect of acute vasodilator testing with oxygen on pulmonary hypertension due to left heart disease.

Status

Recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/09/021441

Enrollment

Registered

2019-09-30

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I272- Other secondary pulmonary hypertension

Interventions

Intervention1: Pulmonary vasodilator testing: Giving 100 percent oxygen through endotracheal tube in mechanically ventilated patients for 10 minutes in cardiac surgery patients. Control Intervention1:

Eligibility

Inclusion criteria

Inclusion criteria: All elective cardiac surgery patients >18 years with left heart disease with estimated Right ventricular Systolic pressure (RVSP) > 40 mmHg by transthoracic echocardiography

Exclusion criteria

Exclusion criteria: i. Patients with shunt lesions like Atrial septal defect, Ventricular septal defect. ii. Patients in whom pulmonary artery catheter insertion is contraindicated such as pnemonectomy, previous lung surgery, pulmonary valvular or infundibular stenosis, tricuspid stenosis, documented pulmonary artery branch obstruction iii. Patients in whom Transesophageal echocardiogram (TEE) placement is contraindicated like esophageal tumours, esophageal perforation, upper Gastrointestinal bleed. iv. Arrythmias with hemodynamic instability

Design outcomes

Primary

Measure	Time frame
To study the effect of acute vasodilator testing with 100% oxygen on change in Pulmonary artery pressure, Transpulmonary gradient, cardiac output, pulmonary vascular resistance due to left heart diseaseTimepoint: parameters are measured at two different level of Inspired Oxygen (FiO2) i. FiO2 of 0.3 and EtO2 between 25 -30% ii. FiO2 of 1 and EtO2 above 95% â?¢ Hemodynamic parameters: These parameters will be measured three times at 2 minutes interval and average of three readings will be calculated. 1. Mean pulmonary artery pressure (m-PAP) 2. Systolic and Diastolic Pulmonary artery pressure 3. TPG, DPG, Cardiac output, 4. SVR, PVR, RVSV 5. SBP, DBP, MBP, HR	—

Measure

Time frame

To study the effect of acute vasodilator testing with 100% oxygen on change in Pulmonary artery pressure, Transpulmonary gradient, cardiac output, pulmonary vascular resistance due to left heart diseaseTimepoint: parameters are measured at two different level of Inspired Oxygen (FiO2) i. FiO2 of 0.3 and EtO2 between 25 -30% ii. FiO2 of 1 and EtO2 above 95% â?¢ Hemodynamic parameters: These parameters will be measured three times at 2 minutes interval and average of three readings will be calculated. 1. Mean pulmonary artery pressure (m-PAP) 2. Systolic and Diastolic Pulmonary artery pressure 3. TPG, DPG, Cardiac output, 4. SVR, PVR, RVSV 5. SBP, DBP, MBP, HR

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Countries

India

Contacts

Public ContactRajkumar S

JIPMER, pondicherry

drajaykjha@rediffmail.com9868477642

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026