Health Condition 1: N189- Chronic kidney disease, unspecified
Conditions
Interventions
Intervention1: Tab Dexamethasone 1 mg single dose orally: To collect two samples of salivary cortisol before Tab Dexamethasone and to collect serum and salivary cortisol after
Tab Dexamethasone 1 mg
Sponsors
Department of endocrinology KEM hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients with clinically stable CKD will be divided on the basis of glomerular filtration rate (GFR) into the following arbitrary four groups: mild (GFR: 60-89 ml/min/1.73 m2), moderate (GFR: 30-59 ml/min/1.73 m2) and severe kidney insufficiency (GFR: 15-29 ml/min/1.73 m2), and patients on haemodialysis. 30 patients from each group, and in addition 30 healthy controls with normal GFR >90 ml/min/1.73 m2) will be recruited.
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1. Patients on exogenous steroid therapy. 2. Subjects on drugs known to alter Dexamethasone metabolism or CBG (cortisol Binding Globulin) status. 3. Patients having gingivitis or oral ulcers. 4. Oral tobacco use Exclusion Criteria for Healthy Volunteers: 1. Pregnancy 2. Subjects on drugs known to alter Dexamethasone metabolism or CBG (cortisol Binding Globulin) status. 3. Subjects having gingivitis or oral ulcers. 4. Oral tobacco use
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To derive normative range of salivary cortisol (8 am and 11 pm) in patients with CKD Performance of overnight dexamethasone suppressed (ODS) cortisol in patients with CKD Timepoint: 12 months | — |
Secondary
| Measure | Time frame |
|---|---|
| NoneTimepoint: None | — |
Countries
India
Contacts
Public ContactRobin Garg
Seth G.S.Medical College and KEM Hospital, Mumbai
Outcome results
None listed