Health Condition 1: L818- Other specified disorders of pigmentation
Conditions
Interventions
Intervention1: Group 1 (laser arm): Fortnightly Q Switched Nd Yag Laser (Med-lite C6 Hoya Con Bio Inc., Fremont, CA, USA) with a fluence 2.0 J/cm2, spot size 6 mm, frequency 10 Hz and 10 to 20 passes
Sponsors
All India Institute of Medical Sceinces
Eligibility
Inclusion criteria
Inclusion criteria: All consecutive patients of lichen planus pigmentosus and pigmented contact dermatitis fulfilling following criteria: 1. 18-50 years of age 2. no progression of pigmentation for past 3 months 3. histologically inactive (defined as absence of interface dermatitis)
Exclusion criteria
Exclusion criteria: 1. Age 2. Coexistent active lichen planus 3. Previous history of laser treatment during the last 12 months 4. Patients on systemic or topical therapy for the past 1 month 5. Not willing to participate in the study 6. Patients having photosensitivity 7. Patients with hypersensitivity to prilocaine or lignocaine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Physician assessment: Two dermatologists blinded to the treatment protocol would independently assess pigment lightening using digital photographs with the following grading scale. o 0-25% (none/ slightly lightening) o 26-50% (moderate lightening) o 51-75% (significant lightening) o 76-95% (very good lightening) o 96-100% (excellent lightening) Also a comparison of side effects in the two groups will be done at the end of trial.Timepoint: 24 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Dermoscopic assessment: The changes in dermoscopy will be compared before and after treatment. Timepoint: 24 weeks;Histopathological assessment: To compare the pigment reduction in pre and post treatment biopsies. Timepoint: 24 weeks;Patient assessment: Patientâ??s subjective assessment will be noted on a visual analog scale ranging from 0-10, (0 - worst and 10 - best results) Timepoint: 24 weeks;Quality of life assessment: patients will be asked to fill Dermatology quality of life questionnaire (DLQI) at the beginning and the end of study, to measure the impact on quality of life with intervention. Timepoint: 24 weeks;Spectrophotometric assessment: Mean change in MI and EI will be calculated in each arm at every month and compared. Timepoint: 4, 8, 12, 16, 20, 24 weeks | — |
Countries
India
Contacts
Public ContactDr G Sethuraman
All India Instiute of Medical Sciences
Outcome results
None listed