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Comparison of two different techniques of general anesthesia drugs administration for development of postoperative lung complications in oral cancer resection surgery with flap reconstruction.

COMPARISON OF TOTAL INTRAVENOUS ANESTHESIA AND INHALATIONAL ANESTHESIA FOR DEVELOPMENT OF POSTOPERATIVE PULMONARY COMPLICATIONS IN ORAL CANCER RESECTION SURGERY WITH PECTORALIS MAJOR MYOCUTANEOUS (PMMC) FLAP RECONSTRUCTION: A PROSPECTIVE, RANDOMIZED CONTROL TRIAL.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/09/021345
Enrollment
80
Registered
2019-09-19
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C01- Malignant neoplasm of base of tongue Health Condition 2: C001- Malignant neoplasm of external lower lip Health Condition 3: C04- Malignant neoplasm of floor of mouth Health Condition 4: C03- Malignant neoplasm of gum Health Condition 5: C06- Malignant neoplasm of other and unspecified parts of mouth

Interventions

Intervention1: Total Intravenous Anesthesia (TIVA): After adequate preoxygenation, anesthesia will be induced with i.v propofol with a target control infusion pump using Schneider model targeting effe

Sponsors

DR BRAIRCH AIIMS NEW DELHI
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients undergoing surgery for elective resection of oral cavity tumor resection with Pectoralis major myocutaneous (PMMC) flap reconstruction. 2. BODY MASS INDEX 18.5- 29.9. 3. ASA PS I, II, III.

Exclusion criteria

Exclusion criteria: 1. Patient refusal. 2. Planned for awake intubation. 3. Planned for central arch resection. 4. Planned for tracheostomy. 5. Emergency exploration. 8. Allergy to Propofol or any study drugs. 9. Ejection fraction 10. Chronic kidney and liver disease.

Design outcomes

Primary

MeasureTime frame
To detect the difference in incidence of postoperative pulmonary complications.Timepoint: over fifth postoperative day.—

Secondary

MeasureTime frame
1.To detect the difference in perioperative systemic inflammation: change between preoperative and postoperative Neutrophil Lymphocyte ratio (NLR), Platelet Lymphocyte ratio (PLR) and modified Glasgow Prognostic Score (m GPS). 2.To detect the change in 24 hour opioid consumption between two groups. 3.To detect intraoperative side effects, i.e.: hypoxia, hypotension, bradycardia.Timepoint: 1. NLR, PLR and the m GPS scoring will be done day before surgery, at the end of surgery and on postoperative day 1. 2. Opioids consumption will be assessed for 24 hours. 3. The side effects will be assessed intraoperatively.—

Countries

India

Contacts

Public ContactDr Seema Mishra

Department of Oncoanesthesia, IRCH, AIIMS, New Delhi

seemamishra2003@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026