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Ajuvants to spinal anaesthesia for Total knee replacements

Comparison of dexmedetomidine vs Buprenorphine as adjuvants to Intrathecal Bupivacaine for bilateral total knee replacement surgeries

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/09/021327
Enrollment
150
Registered
2019-09-19
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M170- Bilateral primary osteoarthritis of knee

Interventions

Intervention1: Spinal anaesthesia: Dexmedetomidine adjuvant to spinal (� Group D (dexmedetomidine Group) will receive 4.0 mL 0.5% hyperbaric bupivacaine with 0.2 mL dexmedetomidine (5 μg) intrathec

Sponsors

Adesh institute
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA I,II, III; willing for spinal

Exclusion criteria

Exclusion criteria: Previous history of spine surgery; infection at injection sign; hypersensitive to local anaesthesia ; mentally retarded; neurological disease

Design outcomes

Primary

MeasureTime frame
Prolonged duration of spinal anaesthesiaTimepoint: Time at which first epidural bolus was given/required

Secondary

MeasureTime frame
Hemodynamic parameters at different interval VAS- T0 Preoperative; T1: After intrathecal; T2: immediate postoperatively; T3: at first request of epidural or rescue analgesia Onset time of sensory: loss of pinprick sensation to 23G hypodermic needle Maximum Sensory block level Time for maximum level of sensory block Motor blockade: Modified bromage score ;onset time of motor blockage to modified bromage grade 3; time for complete motor blockTimepoint: Time to epidural bolus, duration of anaesthesia, half hourly haemodynamics

Countries

India

Contacts

Public ContactDr Jasleen kaur

Adesh university Punjab

drjasleen10@gmail.com9653774212

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026