Health Condition 1: B356- Tinea cruris
Conditions
Interventions
None listed
Sponsors
Indian Association of Dermatologists Venereologists and Leprologists
GCS Medical College Hospital and Research Centre
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients of either sex age between 18 to 60 years. 2. Skin condition clinically diagnosed as dermatophytosis involving non glabrous skin (exluding tinea unguim and tinea capitis) 3. Presence of fungus in scrapping taken from lesion by in KOH preparation. 4. Women of child bearing age must have a negative urine pregnancy test. 5. Patient willing to give written informed consent.
Exclusion criteria
Exclusion criteria: 1. Patient less than 18 years age and more than 60 years.(DOB, govt approved document in case of doubt) 2. Preexisting Cardiovascular, pulmonary, hepatic, renal, hematological, gastrointestinal, endocrine, immunologic, musculoskeletal, neurological or psychiatric disease.(History and medical record) 3. Major surgical or medical illness in last 4 weeks before screening.(History and medical record) 4. Any concomitant medication for purpose other than dermatophytosis management at presentation or within last 4 weeks before screening. (History and medical record). 5. Patient with concommitent asthma, atopic dermatitis allergic rhinitis. Patient with past history of same documented on medical records will also be exluded from study. 6. Patients on corticosteroid or have taken same during last 4 weeks. 7. Patinets who are on at present or treated during last 6 months with any biologic medication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Study of quantitative levels of IFN- γ in serum and expression of same in skin biopsies (using immunohistochemistry (IHC) in paraffin embaded tissue) in patient of dermatophytosis in both study groups. 2. Study of quantitative levels of IL-4 in serum and expression of same in skin biopsies(using IHC in paraffin embaded tissue) in patient of dermatophytosis in both study groups. 6. To study effect of â??priore use of topical or systemic steroidâ?? on study parameters in both group. Timepoint: end of study | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Identificaiton of species of dermatophytosis in both study groups. 2. To study difference in cytokine profile in serum and tissue in both group in relation to mycological species identified. Timepoint: end of study | — |
Countries
India
Contacts
Public ContactDr Nayankumar H Patel
GCS Medical College, Hospital & Research Centre.
Outcome results
None listed