Health Condition 1: K053- Chronic periodontitis
Conditions
Interventions
Intervention1: Immediate-treatment group (Group A): This group will consist of patients with Chronic Kidney Disease and chronic periodontitis who are randomised to the immediate-treatment group. The p
Sponsors
Dr Kirti Satish Dulani
Eligibility
Inclusion criteria
Inclusion criteria: 1. Able to provide informed consent to participate in the trial 2. Follow-up for at least 1 year in Institute of Kidney Disease Research center Ahmedabad prior to recruitment 3. High-risk CKD defined as: (i) A decline of eGFR of 5 ml/min/year or 10 ml/min/5 years; and/or (ii) Urinary proteinuria > 150 mg/dl (iii) CKD stage 1 to 5 (not on dialysis) 5. Generalised moderate-severe periodontitis defined as a minimum cumulative probing depth of 30 mm. This is the sum of the deepest probing pocket per tooth, excluding probing depths
Exclusion criteria
Exclusion criteria: 1. ESRD requiring treatment with RRT 2. Receiving immunosuppression 3. Received specialist periodontal treatment in the previous 1 year 4. Not amenable to periodontal treatment, e.g. severe bleeding disorders that contraindicate periodontal treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Measures of renal function (including serum creatinine, estimated glomerular infiltration rate (eGFR) and urinary Proteinuria. 2. Measures of periodontal health (including Probing Pocket Depth (PPD), Clinical Attachment Loss (CAL) and Periodontal Inflammed Surface Area (PISA) 3. Measure of systemmic inflammation including hs-CRP Timepoint: Baseline, 3, 6, 9, 12, 15, 18, 21, 24 months | — |
Secondary
| Measure | Time frame |
|---|---|
| As diabetes is strong risk factors for both CKD and Chronic periodonttis, glycosylated hemoglobin (Hemoglobin A1c, HbA1c) included as secondary measures.Timepoint: Baseline, 3, 6, 9, 12, 15, 18, 21, 24 months | — |
Countries
India
Contacts
Public ContactKirti Satish Dulani
Government Dental College and Hospital, Ahmedabad
Outcome results
None listed