Health Condition 1: C719- Malignant neoplasm of brain, unspecified
Conditions
Interventions
Intervention1: 3% Saline: 5 ml/kg 3% Saline from the time of skin incision till 1 hour.
Second dose according to the clinical requirement.
Control Intervention1: 20% Mannitol: 5 ml/kg 20% Manniol from
Sponsors
All India Institute of Medical Sciences Bhubaneswar
Eligibility
Inclusion criteria
Inclusion criteria: •18- 60 years •Both gender •ASA I and ASA II •All supratentorial tumors both intraaxial and extra-axial measuring less than 10 cm in any dimension posted for craniotomy in elective neurosurgery OT in AIIMS Bhubaneswar.
Exclusion criteria
Exclusion criteria: 1 Emergency cases 2 Receiving Mannitol or HTS in previous 24 hours 3 GCS 4 Raised serum creatinine > 1.2 mg/dl 5 Preoperative hyponatremia (Na 6 Preoperative hypernatremia (Na >145) 7 Deep location of tumour.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Duration of postoperative hospital stayTimepoint: 1. Duration of postoperative hospital stay- at the time of discharge. | — |
Secondary
| Measure | Time frame |
|---|---|
| 3 months mortality and Glasgow outcome scale extended (after hospital discharge)Timepoint: After hospital discharge, 3 months after hospital discharge;Any complications during ICU stay I Infection II Need for EVD/Shunt placement III Re-exploration IV Reintubation V ICU readmission VI Tracheostomy VII Sodium disorder requiring treatmentTimepoint: During ICU stay;Difference in c-reactive protein between 2 groups after 24 hoursTimepoint: After 24 hours from the time of ICU stay;Difference in serum creatinine between 2 groups at 24 and 48 hoursTimepoint: 24 hours and 48 hours after ICU admission.;Duration of ICU stayTimepoint: Duration of ICU stay in days at the time of discharge from ICU.;Duration of mechanical ventilation (in hours)Timepoint: Mechanical ventilation in hours during ICU stay;Intraoperative and 24 hours fluid requirement (in liters)Timepoint: Intraoperative and first 24 hours in ICU;Need for blood transfusion in the first 24 hoursTimepoint: blood transfusion in first 24 hours during ICU stay | — |
Countries
India
Contacts
Public ContactDr Satyajeet Misra
All India Institute Of Medical Sciences, Bhubaneswar
Outcome results
None listed