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Role of inflammation in skin barrier function and disease severity in children with atopic dermatitis

Th2/Th17 inflammatory cytokines modulating filaggrin expression and disease severity in children with atopic dermatitis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2019/09/021215
Enrollment
40
Registered
2019-09-12
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L209- Atopic dermatitis, unspecified

Interventions

None listed

Sponsors

IADVL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Atopic Dermatitis (Moderate to Severe: SCORAD >25)

Exclusion criteria

Exclusion criteria: Children receiving systemic immunosuppressive therapy in last 1 month Children with serious systemic illness

Design outcomes

Primary

MeasureTime frame
Correlation between Th2/Th17 inflammatory cytokines to epidermal filaggrin expression in children with moderate atopic dermatitis with or without underlying filaggrin mutationTimepoint: Baseline—

Secondary

MeasureTime frame
Correlating the epidermal filaggrin expression to score for atopic dermatitis (SCORAD) and transepidermal water loss (TEWL) in children with atopic dermatitis Correlating the levels of Th2/Th17 inflammatory cytokines to score for atopic dermatitis (SCORAD) and transepidermal water loss (TEWL) in children with atopic dermatitisTimepoint: Baseline—

Countries

India

Contacts

Public ContactNeetu Bhari

All India Institute of Medical Sciences, New Delhi

drntbhari@gmail.com9968722204

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026