Health Condition 1: R888- Abnormal findings in other body fluids and substances Health Condition 2: E282- Polycystic ovarian syndrome
Conditions
Interventions
Intervention1: non surgical periodontal therapy, scaling root planing: to be performed by skilled dentist
the non surgical periodontal therapy will be performed in two weeks with 4-6 sittings of 30 mi
Sponsors
SERB DST
Eligibility
Inclusion criteria
Inclusion criteria: Women between 18 and 30 years of age. 2. PCOS diagnosis will be based on the criteria by Rotterdam2 with the presence of at least two of the following: polycystic ovaries, oligomenorrhea and/or anovulation, hyperandrogenism (clinical and/or biochemical) 3. Diagnosis of generalized moderate-to-severe chronic periodontitis will be based on presence of at least 20 teeth in the oral cavity, with at least 30% of the areas undergoing clinical attachment loss of at least 3 mm and a probing depth of >=5 mm and radiographic evidence of bone loss3. 4. The systemically healthy group will be based on; history of regular menstrual cycles, no clinical or biochemical sign of hyperandrogenism, matching with the PCOS group in body mass index (BMI) and exclusion of PCOS by ultrasound examination. 5. Willingness to sign consent for study including participation with collection of blood specimens 6. Willingness to discontinue OCP for duration of study period up to 18 weeks
Exclusion criteria
Exclusion criteria: Pregnancy 2. History of smoking or any drug usage, including oral contraceptives, systemic antibiotics (during the previous 6 months) or continuous use of NSAIDs 3. History of any dental treatment in the previous six months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| to obtain an association between PCOS and chronic periodontitis To assess and compare serum and salivary bone marker levels in PCOS subjects with or without periodontitis before and after non surgical periodontal therapy To assess and compare bone density levels in PCOS subjects with or without periodontitis before and after non surgical periodontal therapyTimepoint: 0-18 Months | — |
Secondary
| Measure | Time frame |
|---|---|
| serum testorone levels among PCOD females effect of non surgical periodontal therapy on pros symptoms bone marker levels in saliva and serumTimepoint: baseline to six months | — |
Countries
India
Contacts
Public ContactAfaf Zia
ALIGARH MUSLIM UNIVERSITY
Outcome results
None listed