Health Condition 1: F315- Bipolar disorder, current episodedepressed, severe, with psychotic features Health Condition 2: F314- Bipolar disorder, current episodedepressed, severe, without psychotic features Health Condition 3: F332- Major depressive disorder, recurrent severe without psychotic features Health Condition 4: F333- Major depressive disorder, recurrent, severe with psychotic symptoms Health Condition 5: F323- Major depressive disorder, singleepisode, severe with psychotic features He
Conditions
Interventions
Intervention1: Ketamine Hydrochloride: I.V. Ketamine hydrochloride (0.5 mg/kg over 45 min) will be administered by I.V. infusion with the use of syringe pump and will be observed for side effects if a
succinylcholine (0.5-1mg/kg) will be administered as a muscle relaxant after the induction of anesthesia. The stimulus intensity will be determined by a dose titration procedure (starting at 60 mC) an
Sponsors
National Institute of Mental Health and Neurosciences Bengaluru
Eligibility
Inclusion criteria
Inclusion criteria: Both unipolar and bipolar depression of age 18 to 65 who meet ICD-10 criteria for severe depression (with or without psychotic symptoms) is to be taken in study
Exclusion criteria
Exclusion criteria: Patients who have other diagnosed co-morbid psychiatric illness, other diagnosed chronic medical or neurological illness, fulfill criteria for substance dependence according to ICD-10 (Except nicotine) in past one month, Pregnant and post-partum female
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess and compare antidepressant effects of ECT and Ketamine in severe depressive disorder patients (with or without psychotic symptoms)Timepoint: 15 days | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess and compare cognitive deterioration by ECT and ketamine in severe depressive disorder patients (with or without psychotic symptoms)Timepoint: 15 days | — |
Countries
India
Contacts
Public ContactDr Ravi Kumar Sharma
National Institute of Mental health and Neurosciences (NIMHANS), Bangalore-560029
Outcome results
None listed