Measuring the changes in enzymes in the gingival sulcular fluid during orthodontic tooth movement

Estimation of sRANKL and Osteoprotegerin in the gingival crevicular fluid during orthodontic tooth movement

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/09/021173

Enrollment

Registered

2019-09-11

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Orthodontic treatment with canine retraction: the canine retraction will be done post-levelling and alignment using e-chains with bimonthly activation Control Intervention1: Orthodonti

Eligibility

Inclusion criteria

Inclusion criteria: 1) Age group of 13-30 years 2) Minimum of 20 remaining teeth 3) Need for fixed appliance therapy involving tooth extractions 4) Good general and periodontal health (probing depths not exceeding 3 mm in the whole dentition, no radiographic evidence of periodontal bone loss, no more than 10% of sites with bleeding on probing, and no gingival redness or edema)

Exclusion criteria

Exclusion criteria: 1)Patients who would not give informed consent 2)Previous history of habits such as alcohol consumption or tobacco use 3)Ongoing orthodontic or orthopedic therapy 4)Any systemic condition that could affect periodontal status and bone metabolism or that would require premedication for monitoring or treatment procedures (eg, heart conditions, joint replacements, hormonal or bisphosphonate antiresorptive therapies, and chronic therapy with heparin or corticosteroids) 5)Use of antibiotics, corticosteroids, or anti-inflammatory drugs within the last 3 months 6)Professional cleaning or periodontal treatment within the last 6 months.

Design outcomes

Primary

Measure	Time frame
the rate of tooth movement differs with different frequency of reactivation of the orthodontis appliance. this can be assessed by examination of the gingival crevicular fluid enzymes at different time pointsTimepoint: baseline (t0), 4 weeks after retraction (t1), 8 weeks after retraction (t2)	—

Secondary

Measure	Time frame
the rate of tooth movement differs with different frequency of reactivation of the orthodontis appliance. this can be assessed by examination of the gingival crevicular fluid enzymes at different time pointsTimepoint: baseline (t0), 4 weeks after retraction (t1), 8 weeks after retraction (t2)	—

Countries

India

Contacts

Public ContactPriyanka Kenkare

Manipal College of Dental Sciences

siddarth.shetty@manipal.edu

Outcome results