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A study to understand the role of intestinal microorganisms in Irritable Bowel Syndrome and the effectiveness of Yoga and Diet changes as an add-on treatment option

Quantitative profiling of the gut microbiome of IBS patients and evaluating the effectiveness of yoga and dietary modifications as an additional therapy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/09/021167
Enrollment
240
Registered
2019-09-11
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K581- Irritable bowel syndrome with constipation Health Condition 2: K580- Irritable bowel syndrome with diarrhea Health Condition 3: K582- Mixed irritable bowel syndrome

Interventions

Intervention1: Yoga and Dietary Modification: YOGA INTERVENTION: The patients will be advised to practice the yoga module for 1 hour per day, for a period of 12 weeks. DIET MODIFICATIONS: The patie

Sponsors

Saahithya Mahesh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients diagnosed with Irritable Bowel Syndrome based on the Rome IV Criteria at the Department of Gastroenterology, Kasturba Medical College - Manipal. Patients who have not practiced Yoga in the last six months Patients not under any other alternative medicinal therapy Patients committed to practicing three months of Yoga, three to five times a week.

Exclusion criteria

Exclusion criteria: Patients who are on treatment for IBS at least two weeks before stool collection Individuals with a history of intake of probiotics or antibiotics at least three months before inclusion into the study Individuals diagnosed with (or) with a history of chronic organic GI disease, Individuals who had previously undergone abdominal surgery, Individuals with a history of any illness that may affect bowel motility such as diabetes mellitus, or poorly controlled hypo/hyperthyroidism, Individuals with immune deficiency, on immune suppressants, or those who have active psychiatric, neurological, metabolic, renal, hepatic, infectious, haematological, cardiovascular, or pulmonary disease, Individuals with a history of malignancy Pregnant or lactating women

Design outcomes

Primary

MeasureTime frame
Gut microbiome pattern of IBS patients who are the cases and compare it to the gut microbiome of healthy individuals who will serve as controls.Timepoint: 2 Years—

Secondary

MeasureTime frame
The effect of Yoga and Dietary Modifications in the gut microbiome pattern and relative abundance post-intervention will be assessed for patients showing significant improvement as per the IBS-SSS and IBS-QoL QuestionnairesTimepoint: 2.5 years—

Countries

India

Contacts

Public ContactSaahithya Mahesh

Kasturba Medical College

mamatha.ballal@manipal.edu9901466320

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026