Comparing the effect of bone antiresorptive injection Denosumab and bone screws in preventing unwanted tooth movement during straightening of teeth

Comparing the Effect of Denosumab and TADs in Preventing Anchorage Loss - A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/09/021140

Enrollment

Registered

2019-09-09

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Denosumab: Denosumab of dosage 4mg/6mg/8mg (depending on randomization) will be administered locally to the attached gingiva buccal to the right lower and left upper first molars. Contr

Eligibility

Inclusion criteria

Inclusion criteria: 1.Orthodontic patietns who require maximum or absolute anchorage. 2.Angleâ??s Class 1 malocclusion with crowding less than or equal to 4mm. 3.Angleâ??s Class 1 malocclusion with upper and lower anterior proclination.

Exclusion criteria

Exclusion criteria: 1.Immunocompromised patients 2.Hypocalcaemic patients 3.Patients with active carious lesions or periodontitis.

Design outcomes

Primary

Measure	Time frame
No anchorage lossTimepoint: 6 months after start of retraction	—

Secondary

Measure	Time frame
Rate of anterior teeth retractionTimepoint: 6 months after start of retraction	—

Countries

India

Contacts

Public ContactArathi M

Saveetha Dental College and Hospitals

drsaravanadinesh@gmail.com9884115197

Outcome results