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A clinical trial to study the effect of perioperative dextrose solution on postoperative nausea and vomiting

Effect of perioperative dextose infusion on postoperative nausea and vomiting: A prospective, Double blind randomized placebo controlled study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/08/020944
Enrollment
90
Registered
2019-08-28
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K801- Calculus of gallbladder with othercholecystitis Health Condition 2: C509- Malignant neoplasm of breast of unspecified site Health Condition 3: H679- Otitis media in diseases classified elsewhere, unspecified ear

Interventions

Intervention1: Dextrose: 1 litre solution of 5% Dextrose at 100ml/hour Control Intervention1: Normal saline: 1 litre solution of 0.9% Normal saline at 100ml/hour

Sponsors

Department of Anaesthesiology and critical Care
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing elective laparoscopic cholecystectomy ear nose throat surgery and breast surgery requiring general anaesthesia Patients who are nonsmokers Patients comming under American Society of Anesthesiologists Physical Status I and II

Exclusion criteria

Exclusion criteria: Patients refusal Pregnant women and lactating mothers Patients with history of coronary artery disease congestive heart failure Diabetes mellitus Renal insufficiency Gastro esophageal reflux disease and patients receiving antiemetic and steroid medication Abnormal blood glucose on the morning of surgery fasting blood glucose more than 140 mg per dL Patient with increased intracranial tension due to some pathology eg Intracranial space occupying lesion ICSOL meningitis Pseudotumourcerebri Patient unable to give informed consent Patients with BMI more than or equal to 35 Patients will be excluded from analysis if,they require large volume of intravascular fluid treatment for severe intraoperative hypotension or if the surgery progressed to additional procedures or the patient needed a repeat surgical intervention radiological intervention with contrast or anaesthesia

Design outcomes

Primary

MeasureTime frame
To assess the efficacy of administration of 50gms of 5% Dextrose perioperatively in reducing the incidence of PONV in patients undergoing surgery with high risk of PONVTimepoint: 0 to 2hours 2 to 6hours 6 to 24hours 0 to 24hours—

Secondary

MeasureTime frame
To Compare the difference in rescue antiemetic consumption between the study groups to treat PONV in postoperative period the average postoperative pain score and length of stay in PACUTimepoint: 0 to 2hours 2 to 6hours 6 to 24hours 0 to 24hours—

Countries

India

Contacts

Public ContactDr Aloka Samantaray

Sri Venkateswara Institute of Medical Sciences

aloksvims@gmail.com9493547653

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026